T-win® Platform
T-win® immune-modulatory, off-the-shelf therapeutic cancer vaccines have a dual mechanism of action designed to kill both tumor cells and immune-suppressive cells in the tumor microenvironment (TME).

Re-imagining cancer vaccines – the next frontier in immune-oncology
Modulation of the TME potentiates anti-tumor activity via unleashing the tumor killing by effector T cells
T-win® immune-modulatory, off-the-shelf, therapeutic cancer vaccines are designed to kill both tumor cells and immune-suppressive cells in the TME by stimulating activation and expansion of T cells against IDO1+ and/or PD-L1+ cells. Modulation of the TME potentiates anti-tumor activity via unleashing the tumor killing by effector T cells. This novel and highly differentiated mechanism of action sets T-win® therapeutic cancer vaccines apart from approved immune-oncology therapies that block a single immune-suppressing pathway or direct the immune system to target specific antigens.
Immune-modulatory, off-the-shelf therapeutic cancer vaccine candidates designed to have broad utility
T-win® immune-modulatory, off-the-shelf therapeutic cancer vaccines are designed to target established and well-known immune-suppressive antigens that are widely expressed across tumor types, rather than rare or mutant antigens expressed only in a small number of patients’ tumors or tumor types. T-win® therapeutic cancer vaccines are intended to be used “off-the-shelf” – unlike neoantigen cancer vaccines, which must be personalized for each patient.
How T-win® therapeutic cancer vaccines are designed to work
T-win® vaccines deliver peptide epitopes from immune-suppressive antigens, such as IDO1, PD-L1 and arginase-1, to activate and expand T cells specific for those antigens. These T cells induce potent antitumor immune responses within the TME in two ways: (1) direct killing of antigen-expressing tumor cells and immune-suppressive cells; and (2) modulating the TME to potentiate anti-tumor activity via unleashing the tumor killing by effector T cells.
