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IO Biotech Initiates Global Phase 2 Portion of Clinical Trial For T-win® Immunotherapy in Non-small Cell Lung Cancer

Copenhagen, Denmark – May 15, 2019: IO Biotech, a clinical-stage biopharmaceutical company developing novel, immune modulating anti-cancer therapies based on its proprietary T-win® technology, announced the initiation of the Phase 2 portion of a global, open-label, randomized clinical trial studying the investigational candidate IO102 in combination with KEYTRUDA® (pembrolizumab) for the treatment of first-line patients with metastatic non-small cell lung cancer (NSCLC). This follows the safety portion of the trial of IO102 in combination with KEYTRUDA which has been successfully completed.

As noted on clinicaltrials.gov, the IO102-012/KEYNOTE-764 trial is “An Open-label, Randomized, Phase 1/2 Trial Investigating the Safety and Efficacy of IO102 in Combination with Pembrolizumab, with or without Chemotherapy, as first-line Treatment for Patients with Metastatic Non-Small Cell Lung Cancer” and is a global clinical trial expected to accrue 96 patients across more than 20 sites in the US and Europe. Further information on the study design can be found at www.clinicaltrials.gov (NCT03562871).

The IO102-012/KN-764 trial is part of a collaborative agreement with Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside the US and Canada). The clinical trial will be sponsored by IO Biotech, while MSD will supply the trial with KEYTRUDA. The rights to the study results will be shared, and IO Biotech has retained global commercial rights to IO102.

“The enrolment of the first patient in the Phase 2 part of our Phase 1/2 trial for NSCLC represents a major milestone for IO Biotech, and we are excited that our global trial is now active and recruiting patients. The first patient is now being treated in a first-line treatment setting of metastatic non-small cell lung cancer,” said Eva Ehrnrooth, MD, PhD, chief medical officer of IO Biotech. “Through this trial, we expect to get a diverse set of clinical data that will enable us to explore the potential of IO102 when added to the current standard of care.”

IO Biotech’s lead candidate, IO102, is an Indoleamine 2,3-dioxygenase (IDO) derived immune modulating therapy with a dual mode of action - killing both cancer cells and immune-suppressive cells. IO Biotech’s IDO-derived immune modulating therapies previously demonstrated both a favorable safety profile and promising anti-tumor activity in its first human clinical trial of heavily pre-treated patients with NSCLC.

About NSCLC
According to the American Cancer Society (ACS), lung cancer is the leading cause of cancer death. Each year, more people die of lung cancer than colon, breast and prostate cancers combined. The two main types of lung cancer are non-small cell lung cancer and small cell lung cancer. NSCLC is the most common type of lung cancer, accounting for about 85 percent of all cases. According to the ACS, the five-year survival rate for patients suffering from highly advanced, metastatic (Stage IV) lung cancers is estimated to be six percent.

KEYTRUDA® is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.  

About T-win® Technology Platform
IO Biotech’s proprietary T-win technology platform enables identification of compounds with dual mechanism of action targeting and directly killing immunosuppressive cells and tumor cells while indirectly activating other T-effectors, leading to strong anti-tumor responses.

About IO Biotech
IO Biotech is a clinical stage biotech company developing disruptive immune therapies for the treatment of cancer. The pipeline of first-in-class immune modulating anti-cancer therapies is developed by a unique technology platform, T-Win®, enabling the activation of T cells that are specific for immune-suppressive molecules. IO Biotech has a proven track record of progressing preclinical and clinical compounds. The two lead compounds targeting IDO and PD-L1 are in clinical development and several pipeline compounds are in pre-clinical phase. For further information, please visit www.iobiotech.com.

Contacts
Mai-Britt Zocca, PhD, CEO and founder of IO Biotech
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. 

IO Biotech to Participate in Panel Discussion at 30th Annual Cancer Progress Conference in New York

Copenhagen, Denmark – April 30, 2019:  IO Biotech’s CEO, Mai-Britt Zocca, Ph.D., will participate in a panel discussion entitled, “IO Session I: Combination Failures & Futures: Much Ado About What?” at the 30th Annual Cancer Progress Conference in New York City on May 7-8, 2019. 

IO Biotech will participate in the discussion together with senior executives from GlaxoSmithKline, Cancer Research Institute, Parker Institute For Cancer Immunotherapy, Agenus, and KAPital Consulting. The discussion will be moderated by Jeffrey M. Bockman, PhD, Executive Vice President, Head of Oncology Practice, Cello Health BioConsulting.

The discussion is to take place on Tuesday, May 7, 2019 from 3:15 to 4:30 PM at Convene at 32 Old Slip, New York. More information is available at www.cancerprogressbydh.com.

About T-win® Technology Platform
IO Biotech’s proprietary T-win technology platform enables identification of compounds with dual mechanism of action targeting and directly killing immunosuppressive cells and tumor cells while indirectly activating other T-effectors, leading to strong anti-tumor responses.

About IO Biotech
IO Biotech is a clinical stage biotech company developing disruptive immune therapies for the treatment of cancer. The pipeline of first-in-class immune modulating anti-cancer therapies is developed by a unique technology platform, T-Win®, enabling the activation of T cells that are specific for immune-suppressive molecules. IO Biotech has a proven track record of progressing preclinical and clinical compounds. The two lead compounds targeting IDO and PD-L1 are in clinical development and several pipeline compounds are in pre-clinical phase. For further information, please visit www.iobiotech.com.

Contacts
Mai-Britt Zocca, PhD, CEO and founder of IO Biotech
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. 

IO Biotech Presents Data on an Immunomodulatory CCL22-based Vaccine at the American Association for Cancer Research Annual Meeting 2019

Copenhagen, Denmark – April 1, 2019:  IO Biotech Presents Data on an Immunomodulatory CCL22-based Vaccine at the American Association for Cancer Research Annual Meeting 2019 - Promising Data Prompt Planning of Human Clinical Trials -

IO Biotech, a clinical-stage biopharmaceutical company developing novel, immune modulating anti-cancer therapies, based on its proprietary T-win® technology, presented preclinical data on the therapeutic potential of an immunomodulatory CCL22-based vaccine. These data were presented today at the American Association for Cancer Research Annual Meeting 2019 in Atlanta, Georgia.

CCL22 is a macrophage-derived chemokine that exerts immunosuppressive functions by the recruitment of regulatory T-cells to the tumor microenvironment (TME). CCL22 is expressed by cells in the TME in many different cancer types including melanoma, breast, lung and pancreatic cancer and is thought to mediate immune suppression via the recruitment of regulatory CD4+ T-cells.

It has previously been described that CCL22-specific T-cells from cancer patients can kill CCL22-expressing tumor cells, and activation of CCL22-specific T-cells may directly influence the CCL22 concentration in the TME, suggesting that CCL22 may be an interesting target for an immunomodulatory vaccine. In this poster, IO Biotech has tested this concept further, demonstrating that CCL22 vaccination mediates antitumor immunity in two mouse tumor models. Moreover, an assessment of gene expression in the tumors revealed that CCL22 vaccination leads to a direct reduction of tumor growth related to a reduction of CCL22 expression, alongside other immunosuppressive molecules such as IDO1, in the TME. In conclusion, these findings provide a rationale for novel cancer immunotherapy to target the immunosuppressive TME.

"These new findings suggest that it is possible to target and modulate the tumor microenvironment by the targeting of CCL22 expressing cells," said Mai-Britt Zocca PhD, Chief Executive Officer of IO Biotech. "This will enable us to explore the potential of CCL22 vaccination further. Through the coming year, we expect to obtain additional preclinical data and then initiate first-in-human trials."

IO Biotech has a compound, IO140, targeting cells expressing CCL22 in preclinical development.

About T-win technology platform 
IO Biotech's proprietary T-win technology platform enables identification of compounds with a dual mechanism of action targeting and directly killing immunosuppressive cells and tumor cells, and indirectly activating other T-effectors, leading to strong anti-tumor responses.

About IO Biotech 
IO Biotech is a clinical stage biotech company developing disruptive immune therapies for the treatment of cancer. The pipeline of first-in-class immune modulating anti-cancer therapies is developed by a unique technology platform, T-Win, enabling the activation of T cells that are specific for immunosuppressive molecules. IO Biotech has a proven track record of progressing preclinical and clinical compounds. The two lead compounds targeting IDO and PD-L1 are in clinical development, and several pipeline compounds are in pre-clinical phase.

For further information, please visit www.iobiotech.com.  

Contacts
Mai-Britt Zocca, PhD, CEO and founder of IO Biotech
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.